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Stability of tramadol hydrochloride-acetaminophen (Ultracet) in strawberry syrup and in a sugar-free vehicle |
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International Journal of Pharmaceutical Compounding, Sep/Oct 2004 by Foy, Elizabeth, MacCara, Mary E, MacLean, Lindsay STABILITY Stability of tramadol hydrochloride-acetaminophen (Ultracet) in strawberry syrup and in a sugar-free vehicle. Johnson CE, Wagner DS, DeLoach SL et al. Am J Health Syst Pharm 2004; 61(1): 54-57.
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Tramadol The combination of tramadol hydrochloride and acetaminophen has been shown to be effective for pain relief and is well tolerated. Although available in the United States as an oral tablet, Ultracet, there is no commercially available liquid formulation of this drug combination. The authors prepared a liquid suspension of tramadol 7.5 mg/mL and acetaminophen 65 mg/mL in a 1:1 mixture of Ora-Plus and strawberry syrup or Ora-Sweet and tested its stability over a period of 90 days. (Procedure for compounding tramadol 7.5 mg/mL and acetaminophen 65 mg/mL oral liquid is given in the Appendix.) Stability of each drug was determined through chromatographic assays. At least 97% of the initial concentration of both tramadol hydrochloride and acetaminophen was retained in all samples stored in the refrigerator (3-5°C) or at room temperature (23-25°C) for at least 90 days. No detectable changes in color, odor or taste were noted and there was no visible microbial growth. Due to the bitter aftertaste of these suspensions, the authors recommend using chocolate syrup to improve palatability, especially for children. Copyright International Journal of Pharmaceutical Compounding
Sep/Oct 2004 |
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